Sertraline hydrochloride is widely used antidepressant drug but it is very bitter and poses challenge of being administered to depressed person. Generally, a pill design is for swallowing intact or chewing to deliver a precise dosage of medication to patients. However, some patients, particularly pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. In order to assist these patients, fast dissolving films were developed. The films can be consumed without water, thus enabling administration easier in pediatric geriatric and dysphagic patient formulation. The dosage form allows discrete consumption of the dose, and smaller the size of the dosage form allows for shorter residence time within the oral cavity and potentially more effective avoidance of unpleasant taste. To avoid the bitter unpleasant taste sertraline hydrochloride –Beta cyclodextrin complex granules were utilized.
